Ferrer raced through the first set in 21 minutes, playing near-perfect tennis, sealing it with a ferocious backhand pass that fizzed past Gasquet's racquet.
A dejected Gasquet trudged back to his chair and the third seed fared little better in the second set despite encouragement from a Tokyo crowd keen to get their money's worth.
Ferrer, playing his first tournament since reaching the semi-finals of the U.S. Open, broke for 2-0 and never looked like losing his grip on the match.
The 25-year-old wrapped up his third title of 2007 on his first match point, ending Gasquet's bid for back-to-back titles after his victory in Mumbai last week.
"It's very special," said Ferrer. "Not because Federer won last year but because it's on a hard court. My surface is clay and this is only my second hardcourt title (after Auckland).
"To win in Tokyo is special because it's a big tournament -- bigger than Auckland."
Ferrer added: "I knew before the match I had to be very aggressive and I played with a lot of confidence. I'm playing the best tennis of my career now."
Victory in Japan boosted Spaniard's hopes of booking a spot in next month's season-ending Tennis Masters Cup in Shanghai, for which only the top eight players of the year are eligible.
Ferrer is sixth in the ATP Champions Race while Gasquet broke into the top 10 by reaching the final in Tokyo.
Gasquet blamed fatigue for his sluggish performance and jokingly said he regretted not staying up until the early hours to watch France beat New Zealand at the rugby World Cup.
"I played 10 matches in two weeks -- it was a bit too much for me," said the Wimbledon semi-finalist. "I was feeling tired and it was just too difficult."
"I knew the rugby was on TV at 4 a.m. in my hotel but I had to sleep," he added with a sheepish grin. "If I had known I was going to lose 6-1 6-2 I would definitely have watched it."